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The second of Columbia Pictures' four "Wild Bill Saunders" westerns, Pioneers of the Frontier features William Elliott as the title character who discovers that his uncle Mort (Lafe McKee) has been murdered by an unscrupulous ranch foreman, Matt Brawley (Dick Curtis). But before he can right Brawley's wrongs, Wild Bill is arrested for a murder he didn't commit. Sidekick Cannonball Sims (Dub Taylor) and disgruntled girl rancher Joan Darcy (Dorothy Comingore) plot to break Wild Bill out of jail but Brawley is wise to their plan. Wild Bill nevertheless manages to escape and concocts a plan to trap Brawley and his men. The scheme succeeds but before he can settle down, Wild Bill heeds the call of a friend in trouble and rides off to bring law and order to another violent part of the Old West. Preceded by Taming of the West (1939), Pioneers of the Frontier was followed by two additional "Wild Bill Saunders" westerns: The Man from Tumbleweeds and The Return of Wild Bill (both 1940).