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Distributed by NBC Universal Television, The Megan Mullally Show was a daily, hour-long vehicle for the comic actress who'd risen to fame as the annoyingly shrill rich-witch Karen Walker on the long-running sitcom Will & Grace. After guest-hosting David Letterman's chatfest in 2003, Megan Mullally proved so effective in this capacity that she was subsequently invited to interview Madonna for the VH-1 cable channel. Other hosting jobs followed, culminating in Mullally's own starring talk show, which entered syndication on September 18, 2006. Not surprisingly, The Megan Mullally Show was topheavy with celebrity guests, and also featured an abundance of music and comedy, not to mention offbeat "expert" guests and a daily Q-and-A session between the personable Mullally and her studio audience.