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Sally in Our Alley revives the old bromide about the orphan waif who is unofficially adopted by three men of different faiths and ethnic backgrounds. Shirley Mason plays Sally Williams, who has grown up under the watchful eyes of Scotsman Sandy Mack (Alec B. Francis), Italian Tony Garibaldi (Paul Panzer) and Jewish Abe Lapidowitz (William H. Strauss). Upon reaching maturity, Sally falls in love with a neighborhood boy, plumber Jimmie Adams (Richard Arlen). Enter wealthy Chester Drake (Harry Crocker), who offers to take Sally away from her tenement surroundings and her "low-life" friends. Jimmie and the three surrogate fathers unintentionally embarrass Sally at a party thrown at Drake's estate, whereupon the three old men slink dejectedly back to their old neighborhood, while Jimmie signs on with the merchant marine. But Sally decides to forsake wealth and luxury in favor of those who loved and cared for her throughout her life.