Sex Madness is by far and away the most obscure and cheapest-looking of the "Madness Trilogy," which also includes the much better known Reefer Madness and Cocaine Fiends. Yet it is typical exploitation melodrama harking back to the reformist age of the early 1910s. But unlike most films of the genre, Sex Madness spreads its net rather wide and in addition to the topic of venereal disease also discusses the general ill effects of casual sex and lesbianism. The former is shown via the standard "wild party" scene while the latter is merely hinted at in a couple of sequences depicting two stenographers, one a mannish type, the other a more traditional starlet, who are encouraged to explore their "forbidden" desires by attending a rather tame burlesque show. Sex Madness, like most exploitation films, also includes cautionary documentary footage from the World War I era, in this case a parade of syphilis-infected patients (a so-called "square-up" reel), and several completely unrelated variety performances. At one point in the story, the heroine wears a Spanish mantilla for no apparent reason other than to match footage from a hacienda festival "lifted" intact from some Grade-Z Western.