Ambitious to a fault, Bruce Wagner's feature debut -- adapted from his own novel -- is a sprawling, Hollywood-literate ensemble pic that tackles such weighty issues as death, spirituality, and success, but fails to find a consistent tone for the proceedings. Predetermining Six Feet Under's mix of morbidity, sex, and sarcasm by a couple years, I'm Losing You drops pop-culture references and life-threatening illnesses within the same scene -- more often than not, within the same sex scene. It's like Magnolia without the redemption, which isn't necessarily a bad thing, but it's hard to take a vested interest in any of the affluent, abrasive characters, especially Rosanna Arquette's unpredictable adoptive daughter character, whose quest for faith seems more of an arbitrary device than a deep-seated yearning. Best in the cast (as usual) is Elizabeth Perkins, whose AIDS-stricken single mom Aubrey strikes the perfect note of sardonic humor in the face of despair.