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Dave Matthews) is cast as Patrick, a mentally challenged musical savant who begins suffering painful hand constrictions during a concert. House (Hugh Laurie) may be able to cure the ailment by alleviating Patrick's neurological disorder--but in the process, the patient may lose his musical genius, thereby imperiling a big fundraising campaign. Meanwhile, the staff is led to believe that House is suffering from brain cancer--especially after he heads out of town to conduct highly suspicious tests on a patient named "Luke N Laura" (the significance of this monicker will of course not be lost on General Hospital fans!)