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The "wise guys" referred to in the title, Harry Valentini (Danny DeVito) and Moe Dickstein (Joe Piscopo), turn out to be not so wise after all in this crime-oriented comedy. Harry and Moe run the risk of certain death when they steal money from a Mafia don (Dan Hedaya) and then try to multiply their ill-gotten gains at the horse races. Naturally, they lose the bundle and the next thing they know they're running from hitmen and trying to come up with enough cash to pay back their debt. Wise Guys' blend of comedy and action represented something of a change of pace for director Brian DePalma, best known for his offbeat thrillers and Hitchcock homages.