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The inimitable Preston Sturges originally scripted Hotel Haywire with George Burns and Gracie Allen in mind, but by the time the film went before the cameras, the Burns and Allen roles had been recast with Benny Baker and Colette Lyons -- and significantly abbreviated in the process. A dentist named Parkhouse (Lynne Overman) plays a practical joke on a poker-playing buddy by sending him home with a lady's chemise stuffed in his coat pocket. The gag backfires, whereupon Parkhouse finds himself in hot water with his own wife (Spring Byington). Threatened with divorce, Parkhouse is advised by a zany astrologer to frame Mrs. P. in a compromising situation at the Hotel Haywire, enlisting amateur detectives Bert and Genevieve Sterns (Baker and Lyons) in his scheme. Things get really hectic when Parkhouse's daughter Phyllis (Mary Carlisle) and her sweetheart Frank (John Patterson) show up at the same hotel. The film is dominated by the antics of larcenous astrologer Zodiac Z. Zippe, played with comic ferocity by Leo Carrillo.