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Two women get a new and unusual perspective on the doctor/patient relationship in this romantic comedy. Rafi Gardet (Uma Thurman) is a woman in her mid-thirties who has recently gone through a messy divorce. Rafi has been seeing an analyst, Lisa Metzger (Meryl Streep), as she struggles to get back on her feet emotionally and look for new love. Rafi meets a man named David Bloomberg (Bryan Greenberg), and the two quickly hit it off, but Rafi isn't sure if she should pursue the relationship, since David is only 23 years old. After discussing the burgeoning romance during one of their weekly sessions, Lisa urges Rafi to take a plunge with David, and not be afraid to seek out the companionship she needs. However, there's something about David that Lisa doesn't know -- he's her son. Rafi doesn't know that Lisa is David's mother, either, and both psychiatrist and patient are thrown for a loop when they learn the truth. Prime was originally intended to star Sandra Bullock as Rafi, but she dropped out of the project shortly before filming began, reportedly due to disagreements with the director over the script, with Thurman taking her place.