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This Time for Keeps is a followup to 1940's Keeping Company, with Ann Rutherford repeating her role from the earlier film. Rutherford is cast as newlywed Katherine White, at present undergoing a rocky "period of adjustment" with her husband Lee (Robert Sterling, replacing the original film's John Shelton). Having trouble landing a good job, Lee is persuaded to go to work for his father-in-law Harry Bryant (Frank Morgan in the first film, Guy Kibbee in the second). Unfortunately, Harry doesn't believe in allowing his employees to think for themselves, resulting in even more friction between Katherine and Lee. It's up to Harry's all-knowing wife (Irene Rich, another carryover from Keeping Company) to smooth everyone's ruffled feathers.