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Scheming to steal the jewelry owned by wealthy and beautiful Hope Hampton, villain Holbrook Blinn concocts an elaborate scheme to separate Hampton from her fiance Walter Miller. Once Miller has been lured away by sexy cabaret dancer Nita Naldi, Blinn spirits Hampton off to his apartment and slips her a spiked drink. As our heroine snoozes away, Blinn divests her of her jewels then prepares to have his way with her. But in the nick of time, Miller breaks into the apartment and rescues the girl. Rather than sneer "Curses!", the villain unexpectedly breaks out in laughter, as if he'd expected all along to be caught! This curious ending aside, The Unfair Sex had nothing new to offer to filmgoers of the era.