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Thunder Over the Prairie was the second of Charles Starrett's "Dr. Steve Monroe" westerns. The unorthodox plot is set in motion by an evil land baron (Donald Curtis) who uses the local Indians as laborers, then finds legal methods to cheat them of their pay. Dr. Steve Monroe (Starrett), the reservation physician, does his best to thwart the villain by peaceable methods. When all else fails, the good doctor shows himself quite adept with both fists and six-guns. The heroine is played by Eileen O'Hearn, a Columbia contractee never given an opportunity to reach her full potential, while the comedy relief is provided along surprisingly intelligent lines by Cliff Edwards, cast as a mail-order medico.