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Even before the Fox Studios merged with 20th Century Productions in 1935, the company was dedicated to the proposition that three leading ladies were better than one. The "Three Girls Lost" of the title are played by Loretta Young, Joyce Compton and Joan Marsh. Lovely Loretta and wisecracking Joyce do all right by themselves when they leave their home town for wicked old Chicago. Alas, Joan falls in with thieves and sharpsters, forcing the other two girls to help her out. Of particular interest is the presence in the cast of 24-year-old John Wayne, amusingly miscast as a well-groomed socialite.