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Saturnine Arthur Wontner makes his second screen appearance as Conan Doyle's master sleuth Sherlock Holmes in The Missing Rembrandt. The plot is motivated by the perfidious Baron von Guntermann (Francis L. Sullivan), "the worst man in London." Using blackmail as his principal weapon, the Baron manages to decorate the walls of his townhouse with several stolen works of art, including a priceless Rembrandt recently stolen from the Louvre. When an American detective proves unable to capture the elusive Von Guntermann, Sherlock Holmes (Wontner) takes over. Disguised as a priest, Holmes gains entry to the Baron's lair but is soon found out and forced to flee for his life. Reasoning that it takes a thief to catch a thief, Holmes and Dr. Watson (Ian Fleming) resort to burglary to retrieve valuable evidence, only to be accused of the murder of the American detective. Finally, however, Holmes emerges triumphantly, revealing the diabolically clever hiding place for the Missing Rembrandt. The film is based on the Conan Doyle story The Adventure of Charles Augustus Milverton.