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This lively entry in the "Boston Blackie" series finds Blackie (Chester Morris) acting as spiritual leader of a group of ex-convicts. The plan is for the former inmates to redeem themselves by working in a defense plant. Only problem: some of the cons (Douglas Fowley, Arthur Hunnicutt et. al.) have no intention of going straight and are planning a major robbery. Predictably, suspicion falls upon the only honest one (Erik Rolf) in the bunch -- and upon Blackie, who is himself a previous "guest of the state." Chance of a Lifetime represents the first directorial effort of William Castle, who later claimed that, saddled with a hopeless project, he made the film "work" by re-arranging the reels in the editing room (it sure doesn't look like it was put together that way!)