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Sam and Dean investigate a murder at a museum and learn a ghost from a merchant ship that sank in 1723 may be at the heart of the mystery. They also realize the ship is the same one that Crowley's son Gavin should have been aboard, so they enlist help from Rowena to track Gavin down. Meanwhile, Kelly Kline, still pregnant with Lucifer's child, takes refuge with a demon after an angel tries to kill her.