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Technically, the leading character in The Sign Invisible is Lone Deer, a hapless half-breed played by Mitchell Lewis. But the true star of the proceedings is Dr. Robert Winston (Victor Sutherland), who after losing his license and his reputation has become an atheistic alcoholic. Rescued from the depths of despair by Jeanette Mercier (Mabel Juliene Scott), the daughter of a logging-camp proprietor, Winston nonetheless holds fast to his conviction that there is no God. If only he would receive a Sign From Above, declares the doctor, he'd become a true believer again. Meanwhile, Lone Deer desperately pursues his Indian sweetheart, who has been taken away from him by her tradition-bound father. In the course of his pursuit, Lone Deer is shot and left for dead. Though he is certain that he will be unable to save the half-breed's life, Dr. Winston agrees to operate on Lone Deer -- who, though rendered sightless, stages an otherwise complete recovery. Things end happily for both men: The blind Lone Deer is reunited with his Indian maiden, while Dr. Winston, having received the "Sign Invisible," renews his faith in God.