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When antibiotics were discovered, they seemed to be the answer to infections and diseases, and for a number of years, millions of people recovered from disorders with their help. However, bacteria are adaptive, and many have evolved resistance to some of the most powerful medications doctors prescribe. Some diseases, such as tuberculosis, have tough strains that do not respond to anything in the medical arsenal. Perspective: The Old Enemy Returns (Resistant Bacteria) investigates the challenge to researchers, who face the dilemma of even more resistant bacterial strains as time passes.