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Spencer Tracy plays a hard-driving newsman with a special instinct for solving sensational murders before the police can. This earns him the grudging respect of his peers, but his editor always puts him in his place. Tracy spends most of his time solving cases and almost never sleeps at home. This worries his lovely colleague Virginia Bruce who secretly loves him and wants him to settle down. Trouble comes after Tracy's estranged wife commits suicide and con-artists destroy the life of Tracy's dad. Vengefully, Tracy begins plotting the perfect murder of these larcenous crooks. This was Tracy's first film for MGM. He would remain with the studio for the next twenty years. Murder Man also marks the debut of Jimmy Stewart who appears as a cub reporter jokingly named "Shorty."