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G-Man Bill Collins (Preston Foster) swings into action when a crooked sweepstakes racket begins insinuating itself upon the honest citizenry of the US. The crooks have flooded the market with counterfeit lottery tickets, reducing many an unwary speculator to poverty. When he's not tracking down the miscreants, Collins finds time to romance Linda Parker (Irene Harvey), who is innocently involved in the bogus ticket operation. The whole thing winds up in an exciting car chase, which later showed up via stock footage in several Universal serials. Missing Evidence was scripted by Dorrell and Stuart McGowan, later the prime movers of TV's Death Valley Days.