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During a carnival in Venice, Horace Pierpont, a wealthy American (Lewis Stone), falls in love with Fay Kennion (Virgina Valli). Their romance is derailed when she goes over to his apartment and finds the vampy Fifi (Nita Naldi) there. Fay goes down to Algiers, where she marries a former sweetheart, Dr. Alan Mortimer (Edward Earle). Pierpont goes after Fay and when he discovers she has wed, takes a trip with the Mortimers over the desert. Dr. Mortimer is suspicious of the relationship between his wife and the newcomer, and when Pierpont is bitten by a viper, he refuses to treat him if there is a relationship going on. Fay lies so that Mortimer will take care of the wound. Later, she confesses the truth and sends Pierpont away. Eventually Mortimer is killed by an Arab attack, and when Fay runs into Pierpont, he reveals that Fifi was at his apartment that long-ago day to exact revenge. Now that nothing at all stands in their way, the pair reunite. This drama was based on the novel Snake Bite by Robert Hichens, a popular writer of the day.