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Foreman (Omar Epps) takes on the case of Lupe (Monique Gabriela Cumen), a 28-year-old con artist suffering from "brain freeze". At first contemptueous of Lupe because she has never tried to rise above her inner-city surroundings (as he has), Foreman eventually becomes so emotionally involved with the woman that it clouds his medical judgment--a fact that will have serious ramifications in the weeks to come. Meanwhile, House (Hugh Laurie) picks the brain of one of Wilson's ex-wives (Jane Adams) to figure out why Wilson (Robert Sean Leonard) has so much trouble holding on to a woman. This episode was directed by former ER costar Paul McCrane.