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In this polished soap opera from MGM, Robert Taylor plays Chris Claybourne, a dedicated scientist researching a possible cure for spotted fever. However, Chris has a dark side; he has a weakness for gambling and has fallen into debt with a gangster named Fish Eye (Joseph Calleia). While visiting a casino, Chris meets Rita Wilson (Barbara Stanwyck), a gambler's shill who does some modeling on the side. Chris and Rita quickly fall in love, and when Chris is due to leave for South America on a research expedition, Rita begs him to stay with her. However, Fish Eye has been leaning on Chris for his money, and when he asks his brother Tom (John Eldridge) for a loan to pay off the debt, he agrees under one condition -- that Chris leave for South America right away, and without Rita. When Chris ships out, Rita believes that he left her behind because he didn't care for her, and to hurt him, she marries Tom and takes Chris's IOU. However, by the time Chris returns, Rita's marriage with Tom is in tatters and she's desperate to win back Chris's affection. In real life, Robert Taylor and Barbara Stanwyck were an item while shooting His Brother's Wife, and they married three years later.