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Rosanna Arquette guest stars as convict Constance Ferguson, who tries to get out of solitary confinement by swallowing four razor blades--an act of pathetic bravado that earns the contempt of Cristina (Sandra Oh). Elsewhere, the newborn quintuplets and their mother (Margaret Welsh) are suffering serious post-natal problems, with one of the infants close to death. As Izzie (Katherine Heigl) cares for the ailing child, Addison (Kate Walsh) decides that it is time to teach the idealistic intern a painful but necessary lesson. Also, Alex (Justin Chambers) broods obessessively over a medical mistake, which only serves to make Izzie (Katherine Heigl) even more angry with him; and under pressure, George (T.R. Knight) agrees to treat a skin-cancer patient with leeches.