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Meredith (Ellen Pompeo) sullenly continues to cool her jets while Derek (Patrick Dempsey) and Addison (Kate Walsh) consider giving their marriage a second change. Back at work, Meredith and the other interns are nonplussed by a male patient named Shane (Joe Sikora), who is convinced that he is pregnant. Meanwhile, Alex (Justin Chambers) tries to persuade an 18-year-old girl named Nicole (Michelle Ongkingco) to undergo corrective surgery--and at the same time, Nicole gives Alex advice on his relationship with Izzie (Katherine Heigl); George (T.R Knight) finds himself identifying with the long-suffering husband (Reni Santoni) of an overbearing heart patient (Elaine Kagan); and Cristina (Sandra Oh) and Burke (Isaiah Washington) aren't sure whether to let everyone know about what's going on between them.