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Michelle (Reiko Aylesworth) has captured Alvers (Lothaire Bluteau), but despite Gael's (Jesse Borrego) best efforts, the virus has been dispersed in the Chandler Plaza Hotel. Michelle calls Tony (Carlos Bernard) to tell him the bad news, and he's horrified to realize that she's calling from inside the hotel. He tells her to leave immediately, but she refuses, understanding that she might already be infected. Chappelle (Paul Schulze) tells Michelle that she's to shoot to kill if anyone tries to leave. She gets the hotel security chief, Phillips (Doug Savant), to help her keep everyone inside and maintain order. Alvers, knowing he's going to die, tells Michelle he'll tell her everything he knows if she promises to kill him once he starts showing symptoms of the virus. There are 11 other vials in play, and the virus has been modified, as they soon discover when Gael starts showing symptoms within an hour of being exposed. One hotel employee, Margolis (J.D. Cullum), overhears Michelle and Gael talking, and tries to escape. When that fails, he sets off the fire alarm, bringing a crowd of hotel guests down to the lobby. The guests demand to know why they can't leave, and Michelle tells them there's a toxic substance in the air outside the building. This story falls apart when a few people in the lobby start to get nosebleeds, and a full-scale panic breaks out. Meanwhile, Palmer (Dennis Haysbert) reluctantly lies to the police to back up Sherry's (Penny Johnson Jerald) alibi. Jack (Kiefer Sutherland) and Chase (James Badge Dale) allow Amador (Greg Ellis) to escape, hoping he'll lead him to the mastermind behind the virus plot, but their plans backfire, and Jack gets a call from an old friend.