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An established stage actress, Margaret Seddon made the transition to films in 1915. During the silent era, Seddon alternated between motherly roles and haughty matronly types; one of her best parts of the 1920s was Miss Trafalgar Gowes in The Actress, a 1927 adaptation of Arthur Wing Pinero's Trelawny of the Wells. Active until 1951, she essayed minor roles in everything from Gone With the Wind (1939) to the Dr. Kildare films. Margaret Seddon earned an honored spot in the annals of film history as Jane Faulkner, one of the two "pixilated" Faulkner sisters, in Frank Capra's Mr. Deeds Goes to Town (1936); she later toured with her Deeds co-star Margaret McWade in a vaudeville act called "the Pixilated Sisters."