- Met Ruth Jones while they were both at Porthcawl Comprehensive School.
- Joined Radio Wales at 20 years old.
- From 1994 he became the main presenter of Rave, BBC Radio 5s youth magazine and music program.
- For 2009 Comic Relief Brydon performed "(Barry) Islands in the Stream" with Ruth Jones and singer Tom Jones. It reached Number 1 in the UK Single Charts.
- On April 1, 2011 he replaced Ken Bruce on BBC Radio2 as one of his impersonations on April Fools' Day.
- Released his biography, Small Man in a Book in 2011.
- Voices the character Lewton in the Discworld computer game Discworld Noir.
- Took part in Channel 4s Comedy Gala 2010.
- Appointed an MBE (Member of the Order of the British Empire) in the Queen's Birthday Honours in 2013.