- Although she was eliminated after just two episodes when she competed on Season 1 of the VH1 show I Want to Work for Diddy, her appearance led to her own makeover reality show, TRANSform Me.
- Time magazine put Sophia Burset, played by Cox on the Netflix television series Orange Is the New Black, on its list of the Most Influential Fictional Characters of 2013.
- Has a twin brother, M. Lamar, who has appeared on Orange Is the New Black as Sophia before her gender reassignment surgery.
- Ellen Page presented the Stephen F. Kolzak Award to Cox for her work both on and off screen at the 25th Annual GLAAD Media Awards.
- Graced the cover of the June 9, 2014 issue of Time magazine, becoming the first transgender person to do so.