- Began her career as a comedian and had a one-woman show, The Miss Education of Jenna Bush, in which she played the daughter of former president George W. Bush.
- Cowrote, directed and starred in the comedic short The Condom Killer.
- Toured with the political-satire group Gross National Product.
- Performs with The Realest Real Housewives show, in which comedians read transcripts from the Real Housewives franchise.
- Was a recurring guest star on season 3 of The Big Bang Theory before joining the cast as a series regular in season 4.