Empire State native D.B. Sweeney attended both Tulane and New York University. Though he had trouble getting sizeable roles in student productions, upon his graduation he was immediately cast in the Broadway revival of The Caine Mutiny Court Martial. He went on to guest-star stints on such TV series as The Edge of Night and Spencer: For Hire before entering movies, where he scored with the critics for his portrayal of an idealistic, gung-ho Vietnam enlistee in Francis Ford Coppola's Gardens of Stone (1987). While he has accrued several noteworthy screen assignments (including the starring role of a nasty hockey player in 1992's The Cutting Edge), D.B. Sweeney is best remembered for his even-keel portrayal of the tragic Shoeless Joe Jackson in Eight Men Out (1988); if he looked like a "natural" on the ballfield, it was because Sweeney had once actually played minor league baseball with the Kenosha Twins, hanging up his spikes after a knee injury. In addition to his film roles, Sweeney continues working on television. He played Dish Boggett in the miniseries Lonesome Dove (1989) and in 1996 starred in the unfortunately short-lived Fox series Strange Luck in which he played an amnesiac freelance photographer with strange powers that resulted from his being the sole survivor of an airline disaster. Sweeney also still appears in theatrical productions. In the years to come, Sweeney would remain active on screen, appearing in films like Taken 2.
- Best known for playing "Shoeless" Joe Jackson in Eight Men Out and Dish Boggett in the miniseries Lonesome Dove.
- Briefly played minor-league baseball for the Kenosha Twins.
- Is close friends with NHL defenseman Chris Chelios, who is godfather to Sweeney's son, Cade.
- In 2008, flew a CH-46E helicopter in squadron HMM-364, "The World Famous Purple Foxes," in Iraq while visiting troops to promote his movie Two Tickets to Paradise.