The granddaughter of John Barrymore and grandniece of Ethel Barrymore and Lionel Barrymore, Drew Barrymore was born in Culver City, California on February 22, 1975. From there, she didn't waste much time getting in front of the cameras, making her first commercial at nine months and her first television movie, Suddenly Love, at the age of two. Two years later, she made her film debut, appearing as William Hurt's daughter in Altered States (1980). At the advanced age of seven, Barrymore became a true celebrity, thanks to her role as the cherubic Gertie in Steven Spielberg's E.T. The Extra-Terrestrial. The huge success of that 1982 film endeared Barrymore to millions of audience members, but following leads in two more films, Irreconcilable Differences and Firestarter (both 1984), the young actress' career was derailed by drugs and alcohol. She cleaned herself up and wrote an autobiography, Little Girl Lost, which detailed her struggles. In the early 1990s, she entered another phase in her career, gaining notoriety for playing a series of vampy, trampy trailer-park Lolitas. In this capacity, she turned in memorable performances in Poison Ivy (1992), the 1993 made-for-TV The Amy Fisher Story, and Batman Forever (1995).
In 1996, Barrymore's image underwent an abrupt and effective transformation following a brief but memorable role in Wes Craven's Scream and a lead in Woody Allen's Everyone Says I Love You that featured her as a Kelly Girl for the '90s, Barrymore's career received an adrenaline shot to the heart. She began working steadily again, and she reshaped her offscreen persona into that of a delightful and sweet-natured girl trying to mend her ways. This new image was supported by her screen work, much of which featured her as a chaste heroine. Her starring role as the "real" Cinderella in Ever After (1998) was a good example, and it had the added advantage of turning out to be a fairly solid hit. Barrymore's other major 1998 film, The Wedding Singer, was another hit, further enhancing her reputation as America's new sweetheart. The following year, the actress all but put the final nail in the coffin of her wild-child reputation of years past, starring as the nerdy, lovelorn twenty-something reporter who bears the titular condition of Never Been Kissed. That movie not only marked a notable transition in Barrymore's reputation, but an advancement in her cinematic career as well. Expanding her role from actress to producer, Barrymore would continue starring in and producing such efforts as Charlie's Angels (2000), Donnie Darko (2001).
Though some may have suspected that her millennial transition from sweetheart to skull-cracker in Charlie's Angels may have signaled a shift towards more action oriented roles -- and despite her return to the role in Charlie's Angels: Full Throttle (2003) -- Barrymore once again charmed audiences with another emotional comedy, Riding in Cars With Boys in 2001, while Confessions of a Dangerous Mind (2002) found Drew in the role of long-suffering girlfriend alongside Sam Rockwell's unlikely CIA operative. Though the film did not fare particularly well critically or otherwise, Barrymore took a nonetheless interesting turn as an apple-pie wife turned sinister in 2003's Duplex, and held her own against scene-chomper Ben Stiller. Barrymore teamed up with fellow Stiller-flick alumni Owen Wilson for 2004's Date School, and once again played Adam Sandler's sugar sweet girlfriend in director Peter Segal's romantic comedy Fifty-First Dates.
2005 brought yet another openly fluffy romantic comedy with Fever Pitch, in which she played the straight-girl against Red Sox super-fan Jimmy Fallon, but she soon changed gears, signing on to appear in Lucky You, a gambling drama by Curtis Hanson. She was soon back to romcom terretory, with Music and Lyrics and He's Just Not That Into You, but also took on an extremly meaty character role in the 2009 HBO film Grey Gardens, in which she mimiced the particular speech and mannerisms of infamous shut-in "Little Edie" and met with major critical acclaim. Around this same time, Barrymore took on her first directorial effort, helming the modest, young-adult movie Whip It, which critics deemed a solid debut. Barrymore then took on a starring role alongside Justin Long in the 2010 comedy Going the Distance, before signing on to play an environmental activist in the feel-good period movie Big Miracle. She then took a career break in order to focus on her growing family before re-teaming with Adam Sandler in 2014 for the romcom Blended, starred in three seasons of the Netflix comedy Santa Clarita Diet, and launched the syndicated daytime talk show The Drew Barrymore Show on CBS in 2020.