After making her first film appearance at age 13, Josephine Hutchinson attended the Cornish School of Music and Drama. A leading Broadway actress of the late 1920s, Hutchinson was most closely associated with the title role in Eva Le Gailliene's Civic Repertory Company production of Alice in Wonderland. Her impeccable credentials notwithstanding, Hutchinson's earliest movie publicity emphasized the fact that hers was the longest name of any movie leading lady. She spent most of her first filmmaking decade at Warner Bros., acting opposite Dick Powell, Pat O'Brien, and, in The Story of Louis Pasteur (1936), Paul Muni. At Universal, she played the wife of Basil Rathbone in The Son of Frankenstein (1939), an experience she cherished primarily because of the warm camaraderie between her co-stars Rathbone, Boris Karloff and Lionel Atwill. Josephine Hutchinson worked steadily in films and television into the 1970s, most often playing firm, forceful elderly women.