- Began his career at 18 behind the scenes of his mother's movie Evelina and Her Sons.
- Grew up in a filmmaking family; father is Giancarlo Giannini.
- For 10 years worked as an assistant cameraman and cameraman on various productions.
- First appearance on screen was in 2001's Alla rivoluzione sulla due cavalli.
- Starred opposite Madonna in the 2002 U.S. remake of Swept Away; played the role his father originated in the 1975 Italian version; Madonna was unaware of the connection until after she chose him.
- In Italy, dubbed Heath Ledger's lines as The Joker in The Dark Knight and won the 2009 Silver Ribbon Award for Best Voice Actor; his father dubbed Jack Nicholson's Joker role in 1989's Batman.
- Directed the 2009 short film Il Gioco (The Game).
- His first role in a U.S. TV series came in 2012 as Giancarlo Rossi in Missing.
- Speaks fluent Italian, English, French and Spanish.