Like a lot of young, hopeful actors, Eric Dane set his sites on Hollywood after showing his stuff in high-school theater productions. He moved to L.A. after graduation, and immediately started paying his dues appearing in things like the TV movie Seduced by Madness: The Diane Borchardt Story and The Basket. Almost ten years of getting by with minor appearances finally paid off for Dane in 2003, when he began appearing regularly on the popular sci-fi dramedy Charmed. He would continue to appear on the show through the next year, a year that would also see him get married to actress Rebecca Gayheart. He appeared in X-Men: The Last Stand in 2006, which was, oddly enough, directed by Brett Ratner, his new wife's former fiancé, and that same year he joined the cast of the wildly popular series Grey's Anatomy. Dane played womanizing plastic surgeon Dr. Mark Sloan (aka "McSteamy"), whose prior affair with Dr. Addison Montgomery-Shepherd (Kate Walsh) contributed to the end of her marriage to his colleague and former best friend, Dr. Derek Shepherd (Patrick Dempsey). In 2008 he was cast in the hit Marley & Me even as he continued work on Grey's Anatomy. In 2010 he appeared in the musical Burlesque and was part of the large ensemble in the romantic comedy Valentine's Day.