Tthe son of blues singer Dori Spears, and a standup comedian since the age of 14, Aries Spears had his first major film role in John Leguizamo zany comedy The Pest (1996). Spears has guest starred on television and hosted various television comedy and music specials. In the late '90s, he joined the cast of Fox television's fast-paced, funny sketch comedy show Mad TV, where he has attracted positive reviews for his dead-on impersonations of James Brown. Spears' other film credits include small roles in Malcolm X (1992), Out of Sync (1994), and Jerry Maguire (1996).
He joined MADtv in 1997, and stayed with the sketch show for 8 seasons; at the same time, he also provided the voice for Wizard Kelly on the Disney Channel animated sitcom The Proud Family. Spears appeared in pair of 2007 episodes of CSI: Miami, and had his own comedy special air on Showtime in 2011.