- A seven-time winner of the Filmfare Award for Best Actor - Telugu.
- Won the Nargis Dutt for Best Feature Film on National Integration as the co-producer of Rudraveena (1988).
- Founded the Chiranjeevi Charitable Trust in 1998, a blood and eye bank.
- Received the Padma Bhushan, India's third highest civilian award, in 2006.
- Founded the political party Praja Rajyam in 2008.
- Member of the Rajya Sabha since 2012.