First introduced to music by his father, who was a professional mariachi violinist.
Renowned music career took off after his performance at Woodstock in 1969.
Inducted into the Rock and Roll Hall of Fame in 1998.
Established the nonprofit Milagro Foundation in 1998, which supports disadvantaged youth in the areas of arts, education and health.
Revived his career and swept the 1999 Grammys with his album Supernatural, which featured duets with a number of contemporary artists, including Eric Clapton, Rob Thomas, Lauren Hill, Dave Matthews and Wyclef Jean.
Launched a women's shoe line, Carlos by Carlos Santana, in 2000.
Ranked No. 15 on Rolling Stone's list of the 100 Greatest Guitarists of All Time in 2003.