- Got her start in the entertainment business by doing stand-up at comedy clubs in Los Angeles in the late 1980s.
- Appeared in four seasons of In Living Color, which was created by her brother Keenen Ivory Wayans.
- In 2007, wrote and starred in her one-woman play titled A Handsome Woman Retreats.
- Cowrote a series of children's books with her husband called Amy Hodgepodge.
- Has been a guest speaker at Camp Harmony retreat for inner-city kids in Los Angeles.