- First job after college was as a news researcher at KGW-TV in Portland, OR.
- Worked as a consumer reporter at WCBS-TV in New York before joining ABC in 1981, serving as a consumer reporter for Good Morning America and 20/20.
- Was struck by pro wrestler David Schultz during a 1984 20/20 interview after Stossel asked if pro wrestling was fake.
- Was promoted to co-anchor of 20/20 in 2003; left ABC in 2009 to join Fox News.
- Is the author of a 2004 autobiography, Give Me a Break, as well as Myths, Lies and Downright Stupidity (2006).
- In addition to numerous Emmys, has won George Polk and Peabody awards, as well as several National Press Club awards.
- Overcame stuttering early in his career and is an active supporter of the Stuttering Foundation of America.