Born September 8, 1971, to a family of entertainers, David Arquette is the youngest brother of actors Rosanna Arquette, Patricia Arquette, and Alexis Arquette, and the son of veteran bit-part actor Lewis Arquette. During David's early years, the family lived on a Virginia commune, but moved to Los Angeles so that Rosanna could pursue an acting career. David first brought his quirky, eccentric persona to the small screen in 1989, with a television adaptation of the film The Outsiders. He had his big screen debut in 1992, when he performed in a number of films, including Buffy the Vampire Slayer and Where the Day Takes You. Small roles in subsequent features followed, including 1994's Airheads, but it wasn't until his turn as a bumbling deputy in Wes Craven's Scream (1996) that he began to receive wider recognition. The same year, his visibility was further increased by a secondary role in Beautiful Girls and his turn as a struggling prostitute in Johns.
1997 brought with it Scream's highly successful sequel, the accurately titled Scream 2. In addition, it brought Dream With Fishes, a film that Arquette both acted in and co-produced. 1999 was a busy year for the actor, signaling that Hollywood was finding more room to accommodate his offbeat talent. In addition to his recurring spot in a series of creepy AT&T commercials, Arquette had major roles in three movies, the Drew Barrymore romantic comedy Never Been Kissed, Muppets From Space, and Antonia Bird's much maligned Ravenous. Arquette further increased his Hollywood visibility with his marriage to Courteney Cox, whom he wed in April 1999.
He starred in the wrestling film Ready to Rumble in 2000, and returned to the Scream franchise that same year for the third film in that series. The next year he appeared as a death camp prisoner in The Grey Zone, and had a part in the action comedy 3000 Miles to Graceland. He starred in the giant-spider movie Eight Legged Freaks and played the father in The Adventures of Shark Boy and Lava Girl.
In the mid-2000s, Arquette began working mostly in television, but in several different jobs. He directed several episodes of his sister Patricia's show, Medium, and acted as a producer with then-wife Cox on her series Dirt and Cougar Town (he was also a guest star on Medium and Cougar Town). Arquette continued to act, though, and had guest spots on Pushing Daisies and My Name is Earl before returning to the Scream franchise once again in 2011 (even though Arquette and Cox had separated by this point and were headed towards a divorce).
Arquette began voicing Skully the parrot on the Disney Junior series Jake and the Neverland Pirates in 2011, and continued the role in the 2014 spin-off, Jake's Buccaneer Blast.