Originally released as La Granda Caccia, East of Kilimanjaro was filmed on location in Africa. Marshall Thompson plays American photojournalist Marsh Conners, assigned to cover a cattle epidemic. Falling in love with research scientist Dr. Marie Avedon (Gaby Andre), Conners attempts to help her convince the Masai tribesmen to have their cattle inoculated, and to locate the source of the disease. While the plot proper ends happily, the romantic subplot is less satisfying. East of Kilimanjaro was also distributed as The Big Search.