When some of cartoonland's biggest bad guys show up to make trouble, it's up to Mickey Mouse and his pals to set things right in this direct-to-video animated adventure. Mickey (voice of Wayne Allwine) and his pals, including Donald Duck (voice of Tony Anselmo), Goofy (voice of Bill Farmer), and Minnie Mouse (voice of Russi Taylor), are relaxing at Mickey's house, looking back at some of their past exploits, when a number of villains they've tangled with before -- including Captain Hook (voice of Corey Burton), Cruella De Ville (voice of Susan Blakeslee), Jafar (voice of Jonathan Freeman), Hades (voice of James Woods), and more -- appear en masse, determined to take over the House of Mikey in the name of evildoers everywhere. Mickey's House of Villains contains many clips from classic Disney cartoons of the past, re-edited to fit the film's new storyline.