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Gangster boss Beau Gardner (Douglass Dumbrille) isn't happy about the things being said about him on the radio station owned by J. J. Held (Berton Churchill). Using his influence, Gardner is able to shut down Held's operation, but he can't wipe out an entire radio network. Thus, he uses hot-shot broadcast engineer Neil Bennett (Lloyd Nolan) as an innocent dupe in a scheme to jam all radio transmissions within shouting distance. Bennett finally manages to enlist the aid of the U.S. Navy to strike a blow for freedom of the airwaves. And how does Ann Sothern fit into all this? Simple: she plays Bennett's sweetheart Fay Stevens, who happens to be a singer at Garner's nightclub. You May Be Next was also released as Panic on the Air, Calling All G-Men and Trapped by Wireless.