Amy Warner (Melora Hardin) and Michelle Mudd (Dana Hill) are two 12-year-old girls with one thing in common: Their parents are going through the process of a divorce. Both girls are angry and resentful, especially because they feel they've been "deserted" by their fathers. Out of their grief the girls form a strong bond of friendship, promising eternal loyalty and respect, and never to betray their trust. But what will happen when circumstances cause Amy to believe that Michelle is turning her back on her? What Are Best Friends For? is based on a novel by Mildred Ames.