A good Samaritan becomes the victim of voodoo spells in this horror story produced by Scream screenwriter Kevin Williamson. When an aged Creole woman is caught in a car wreck in a remote section of Louisiana, Ray (Rick Cramer), the owner of a nearby filling station, speeds to the scene of the accident to help. However, Ray doesn't know that the woman is a voodoo practitioner whose vehicle holds a case full of magic talismans. The magical spirits lead Ray to an unexpected death, and then they take over his body, turning him into a bloodthirsty monster. As the reanimated Ray makes his way into town, a group of teenagers including Eden (Agnes Bruckner) and Tammy (Bijou Phillips) find themselves running for their lives from the supernatural creature, while Deputy Turner (Method Man) looks for a way to keep the strange menace under control. Venom went into release in the fall of 2005 -- only a few weeks after Hurricane Katrina devastated much of the state of Louisiana, making the film seem unfortunately topical.
by Mark Deming synopsis