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Home on the Prairie finds Texas ranger Gene Autry trying to halt an anthrax epidemic. The villains are cattlemen Walter Miller and Gordon Hart, who've been knowingly transporting diseased cattle across the US-Mexico border. The bad guys try to pin the blame on female rancher June Storey, but Gene doesn't buy this subterfuge. Despite the unpleasantness of its storyline, Home on the Prairie is likeable entertainment, especially when Autry dismounts long enough to sing of couple of songs. Joining in on the tunefests are Gene's sidekick Smiley Burnette and a radio aggregation called the Rodeoliers.