In this romantic comedy, a man loses the love of his life, only to find her heart beating in the body of someone new. Architect Bob Rueland (David Duchovny) is happily married until his wife Elizabeth (Joely Richardson), a zoologist, dies in an auto accident. A year later, Bob is still dealing with his loss when he meets Grace Briggs (Minnie Driver), a shy woman who waits tables in an Irish/Italian restaurant run by her grandfather Marty (Carroll O'Connor). Bob falls for Grace at first sight, and she's attracted to him as well, but what he doesn't know is that a year ago Grace was the recipient of a heart transplant -- and that Elizabeth was the donor. Return to Me was directed and co-written by actress Bonnie Hunt, who also appears in a supporting role as Grace's best friend Megan; the cast also includes Robert Loggia, James Belushi, and David Alan Grier.
by Mark Deming synopsis