Time of the Beast (1989)

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A scientist (Brion James) who once worked for a high-tech genetics lab has come back in disguise to work as a security guard so that he can free the lab's abused animals. However, the lab has also created a chimera, a man/animal combination, which, in this thriller, is a very violent creature. Once it gets free from its captors, it goes on a killing spree, and the security guard finds himself having to really get into the spirit of his new job.