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Celebrated genetic engineers Clive (Adrien Brody) and Elsa (Sarah Polley) conduct a clandestine experiment to create an animal/human hybrid that could revolutionize modern medicine -- if it doesn't destroy humanity first. On the heels of engineering an entirely new species of animal, Clive and Elsa become the toast of the scientific community. Their experiment begins to spiral out of control, however, when the superstar scientists introduce human DNA into the equation. When Dren is born, Clive and Elsa welcome her into the world as the next leap in human evolution. Now, the faster Dren evolves, the more her creators start to realize they may have made a catastrophic mistake.